> Scale-Up & Manufacturing
Manufacturing Areas
Delmar has six manufacturing areas in addition to the pilot plant. All of the vessels are serviced through on-line nitrogen inerting, steam and hot water heating and methanol/water cooling. All of the areas have steel grid mezzanines that allow access from both the upper and floor levels. The manufacturing areas are also serviced with a variety of on-line solvents. All of the manufacturing areas along with the equipment found in each are listed below.
This is followed by a general listing of specialized manufacturing equipment that is located elsewhere or may be used in one or more manufacturing areas.
Production Area #1
occupies an area of approximately 330 m2 with a total of 16 vessels and auxiliary equipment. An equipment washing room is also located in this area.
Equipment
- > Reactors
- 1200 litre S/S with packed fractionation column (23 theoretical plates) with high temperature (230°C) and high vacuum (2 mm Hg) capabilities
- 6200 litre S/S with low temperature (-80°C) capabilities
- 7100 litre S/S
- 2200 litre Glass lined (G/L)
- 3300 litre G/L
- 4100 litre G/L
- 3 x 4200 litre G/L
- 3 x 7600 litre G/L
- > Tanks
- 2650 litre S/S
- 2800 litre S/S
- 3300 litre G/L
- 4100 litre G/L
- > Addition tanks (S/S and G/L)
- > Liquid nitrogen cooling system
- > Hot oil heating system
- > High vacuum pump
- > Electronic balances
- > Pumps
- > Air purification tower
Production Area #2
occupies a floor space of approximately 320 m2, including two milling and packaging rooms and atmospheric tray dryers located in this area. The milling rooms are isolated from the other areas by a gowning room with air controls.
Equipment
- > Reactors
- 2 x 6900 litre S/S
- > Three holding tanks for mother liquors and waste
- > Hastelloy C Tolhurst vertical centrifuge (48″ diameter) with receiving tank and elevating platform
- > Caustic storage tank (4775 litre capacity)
- > Atmospheric tray dryers
- > Electronic balances
- > Pumps
Isolation Room #1
occupies an area of approximately 65 m2 and contains an air scrubbing system.
Equipment
- > Reactors
- 3900 litre Hastelloy C
- 2100 litre Glass lined (G/L)
- 4200 litre G/L
- > Three-stage caustic packed air purification tower
- > Addition tanks
- > Electronic balance
- > Vacuum pump/pumps
Isolation Room #2
occupies an area of approximately 65 m2 and has self-contained centrifugation and drying capabilities.
Equipment
- > Reactors
- 2 x 3300 litre Glass lined (G/L)
- > Air purification tower
- > S/S Centrifuge (48″ diameter)
- > Atmospheric tray dryer
- > Addition tanks
- > Electronic balance
- > Pumps
Isolation Room #3
occupies an area of approximately 65 m2 that was newly equipped and renovated in the late 1990s so that all service lines are enclosed behind white, easy-to-clean walls. This area also has a self-contained scrubbing system that filters the air in the room.
Equipment
- > Reactors
- 1900 litre Glass lined (G/L)
- 2 x 3800 litre G/L
- > Three-stage caustic packed air purification tower
- > Addition tanks
- > Electronic balance
- > Vacuum pump/pumps
Hydrogenation Room
occupies an area of approximately 40 m2 in an external area with explosion panels that meet current regulations.
Equipment
- > Reactors
- 400 litre S/S pressure vessel rated to 20 bar (250 psi)
- 2 x 800 litre Glass lined (G/L) hydrogenators rated to 4 bar (60 psi)
- > Hydrogen flow control equipment
- > Electronic balance
- > Pumps
Other Manufacturing Equipment
- S/S Robatel horizontal peeler centrifuge (1.35 m diameter), in an isolated area with separate air control
- S/S Comber agitated pan vacuum dryer (2000 litre) installed in an isolated area with its own air control
- Column lift for loading agitated pan vacuum dryer
- Hastelloy C Comber agitated pan vacuum dryer (1200 litre)
- Hastelloy C Comber filter dryer (3 m2), installed in isolated area with its own air control
- Lyophilizer (180 ft2) installed in isolated area with its own air control
- 4 x Teflon coated single plate portable Aurora filter dryers (48″ diameter)
- 2 x S/S Single plate portable filter dryers (48″ x 48″)
- Portable mill – Fitzpatrick
- Portable compactor – Fitzpatrick
- Horizontal plate Sparkler pressure filters
- High pressure washer system
- Portable addition tanks
- Atmospheric tray dryers
- Portable pumps